2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P11178
    Corisin 2651277-02-8 99.45%
    Corisin is a pro-apoptotic small peptide produced by Staphylococcus species. Corisin binds to serum albumin to target organs such as the lungs and kidneys, induces cellular senescence, apoptosis and epithelial-mesenchymal transition, and accelerates the progression of organ fibrosis including pulmonary fibrosis and diabetic renal fibrosis. Corisin levels are closely associated with coronavirus disease 2019 (COVID-19), diabetic chronic kidney disease (CKD), non-diabetic CKD, and idiopathic pulmonary fibrosis (IPF).
    Corisin
  • HY-P11237
    Enicepatide 2869147-44-2 98%
    Enicepatide is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist. Enicepatide can be studied in antidiabetic research.
    Enicepatide
  • HY-P11290
    MC4-NN2-0453 1228015-10-8 99.15%
    MC4-NN2-0453, a α-MSH analog, is a selective MC4R agonist. MC4-NN2-0453 can be used for obesity research.
    MC4-NN2-0453
  • HY-P11469
    PG-901 322639-20-3 99.35%
    PG-901 is a full, selective MC5R agonist (EC50 = 0.072 nM for hMC5R). PG-901 is also a full antagonist at the hMC3R and the hMC4R (Kb: 1.0 nM and 0.53 nM, respectively). PG-901 significantly diminishes Cytokines (IL-1α, IL-1β, IL-6). PG-901 increases glucose tolerance, reduces blood glucose, decreases retinal damage.
    PG-901
  • HY-P11578
    CKGGRAKDC (linear) 729612-73-1 98%
    CKGGRAKDC (linear) is an adipose tissue homing peptide. CKGGRAKDC (linear) binds to vasculature-enriched prohibitin in adipose tissue to enable selective tissue targeting. CKGGRAKDC (linear) can be used to selective delivery of cargos to adipose tissues.
    CKGGRAKDC (linear)
  • HY-P11672
    Poterepatide 3058127-20-8 98%
    Poterepatide (HDM1005) is a long-acting GLP-1R/GIPR peptide dual agonist. Poterepatide exhibits potent activity on both GLP-1 and GIP receptors. Poterepatide can be used for the study of obesity and type 2 diabetes.
    Poterepatide
  • HY-P1544A
    Cerebellin TFA
    Cerebellin TFA is a neuromodulatory hexadecapeptide that serves as a marker for Purkinje cell maturation. Cerebellin TFA stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway. Cerebellin TFA reduces insulin secretion from pancreatic islets under high-glucose conditions. Cerebellin TFA also regulates synaptic structure formation and controls catecholamine secretion in peripheral tissues. Cerebellin TFA can be used in neurological research.
    Cerebellin TFA
  • HY-P1809A
    Velmupressin acetate 1647120-04-4 99.47%
    Velmupressin (c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2) acetate is a potent, selective and short-acting peptidic V2 receptor (V2R) agonist with EC50s of 0.07 and 0.02 nM for hV2R and rV2R, respectively.
    Velmupressin acetate
  • HY-P2222A
    DX600 TFA 99.20%
    DX600 TFA is a selective ACE2 specific inhibitor (KD: 1.3 nM), and does not cross-react with ACE. DX600 TFA exacerbates diabetes-induced cardiovascular dysfunction and the increase in cardiac and renal NOX activity.
    DX600 TFA
  • HY-P2279A
    Parathyroid hormone (1-34) (rat) acetate 99.87%
    Parathyroid hormone (1-34) (rat) (acetate) is a parathyroid hormone. Parathyroid hormone (1-34) (rat) improves both cortical and cancellous bone structure. Parathyroid hormone (1-34) (rat) can be used for the research of osteoporosis.
    Parathyroid hormone (1-34) (rat) acetate
  • HY-P2812A
    Phospholipase D, peanut 9001-87-0
    Phospholipase D, peanut is an important signaling enzyme in mammalian cells. Phospholipase D, peanut catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid (PA) and choline .
    Phospholipase D, peanut
  • HY-P2871A
    α1-3,6 Galactosidase, Xanthomonas manihotis 9025-35-8
    α1-3,6 Galactosidase, Xanthomonas manihotis is a highly specific exoglycosidase that catalyzes the hydrolysis of α1-3 and α1-6 linked galactose residues from oligosaccharides.
    α1-3,6 Galactosidase, Xanthomonas manihotis
  • HY-P2879A
    Cholesterol esterase, Porcine pancreas 9026-00-0
    Cholesterol esterase, Porcine pancreas is an enzyme that hydrolyzes cholesteryl esters into cholesterol and free fatty acids in the intestine. Cholesterol esterase, also known as bile salt-stimulated lipase or carboxyl ester lipase, functions to promote cholesterol absorption.
    Cholesterol esterase, Porcine pancreas
  • HY-P4146B
    Survodutide sodium 98%
    Survodutide (BI 456906) sodium is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide sodium, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide sodium has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake.
    Survodutide sodium
  • HY-P4928A
    Biotinyl-Amylin (mouse, rat) TFA
    Biotinyl-Amylin (mouse, rat) TFA is a biotinylated Amylin (mouse, rat). Amylin (mouse, rat) is a 37-aminoacid pancreatic protein that exerts control over several metabolic events such as glycemia and lacticemia.
    Biotinyl-Amylin (mouse, rat) TFA
  • HY-P5766A
    AChRα(97-116) TFA 98.12%
    AChRα(97-116) TFA, a peptide, can be used to induce experimental autoimmune myasthenia gravis (EAMG)
    AChRα(97-116) TFA
  • HY-P99816
    Ralpancizumab 1407495-04-8
    Ralpancizumab is a selective PCSK9 inhibitor with potential application in hemorrhagic stroke.
    Ralpancizumab
  • HY-U00159
    McN3716 69207-52-9
    McN3716 is a carnitine palmitoyltransferase I (CPT-1) inhibitor.
    McN3716
  • HY-Y0136R
    3-Indoleacetonitrile (Standard) 771-51-7 98.30%
    3-Indoleacetonitrile (Standard) is the analytical standard of 3-Indoleacetonitrile. This product is intended for research and analytical applications. 3-Indoleacetonitrile is an indole derivative with anti-influenza activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV.
    3-Indoleacetonitrile (Standard)
  • HY-Y1636S
    Fmoc-Arg(Pbf)-OH-13C6,15N4 1217461-89-6 98.3%
    Fmoc-Arg(Pbf)-OH-13C6,15N4 is the 13C-labeled and 15N-labeled Fmoc-Arg(Pbf)-OH (HY-Y1636). Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis).
    Fmoc-Arg(Pbf)-OH-13C6,15N4
Cat. No. Product Name / Synonyms Application Reactivity